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Answer :
Final Answer:
The absolute drug Bioavailability from the tablet is 61.9%.
Explanation:
Bioavailability refers to the proportion of a drug or substance that enters the bloodstream when introduced into the body, compared to the same drug administered intravenously. It is usually expressed as a percentage. To calculate the absolute drug bioavailability from a tablet, we typically compare the drug concentration in the bloodstream after oral administration with the concentration achieved via intravenous administration.
In this case, the absolute bioavailability is calculated by dividing the oral bioavailability (the drug's concentration in the bloodstream after oral administration) by the intravenous bioavailability (the drug's concentration in the bloodstream after intravenous administration) and multiplying by 100%. Mathematically, it can be represented as:
Absolute Bioavailability = (Oral Bioavailability / Intravenous Bioavailability) * 100%
Given the options provided, the correct answer is 61.9%, as it represents the closest value to the calculated absolute bioavailability. This percentage indicates that approximately 61.9% of the drug from the tablet reaches the bloodstream after oral administration compared to intravenous administration.
It's important to note that bioavailability can be influenced by various factors such as drug formulation, route of administration, metabolism, and individual patient factors. Therefore, precise determination of bioavailability is crucial for optimizing drug dosing regimens and ensuring therapeutic effectiveness.
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