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Answer :
Final answer:
The first step in generating C5 convertase in the complement system's classical pathway is the binding of C1q to an antigen-antibody complex on the invading pathogen, initiating the complement cascade.
Explanation:
The first step in generating the C5 convertase in the classical pathway of the complement system is binding of C1q to the pathogen surface. Specifically, C1q binds to an antigen-antibody complex on the invading pathogen. This event triggers the activation of the C1 complex, which in turn causes the cleavage of complement components C2 and C4 into two parts.
The larger fragment of C4, C4b, then binds to the pathogen surface, which is an essential step in the formation of C3 convertase. C3 convertase then acts to split C3 into C3a and C3b, with the latter joining C3 convertase to form C5 convertase, leading to the activation of the rest of the complement cascade and formation of the membrane-attack complex (MAC).
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